Lung protective mechanical ventilators are placed on patients with severe respiratory failure due to COVID-19 induced ARDS to prevent barotrauma. However, because the device is invasive, the patient is much more prone to secondary bacterial infection that can exacerbate critical conditions in patients. Therefore, appropriate antibiotics are usually taken while on the ventilator. To enhance patient-ventilator synchrony, sedation is generally required, although neuromuscular blockade is not generally recommended.