Brain iron deficiency (BID) leads to glutamate, adenosine, and dopamine dysfunction. It is essential to the pathophysiology of Restless Leg Syndrome (RLS) and other symptoms.

Cedarville University

- Iron deficiency is the most common nutritional deficiency
- It's early manifestation can alter sleep structure
  - Structural abnormalities may persist years after it has been cured


Iron Deficiency and Sleep Structure

Silvestri, R., & Ipsiroglu, O. S. (2022). Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental disabilities and restless sleep. Frontiers in psychiatry, 13, 1003019. https://doi.org/10.3389/fpsyt.2022.1003019

Behavioral sleep medicine—The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental disabilities and restless sleep

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