- ivermectin inhibits the IMPa/B1 import and enhances antiviral response
- CD147 is a key receptor for SARS-CoV-2 like ACE2
- ivermectin shields the SARS-CoV-2 spike protein from binding to CD147 or ACE2
- role with P2X4 still needs to be further studied

State University of New York at Stony Brook

Anthelmintic drugs act on parasites and roundworm infections. The drug has shows promise in treating viral diseases, specifically in SARS-CoV-2 by also reducing viral RNA. However, since the drug is an anthelmintic, the FDA has warned against it for use against the novel coronavirus.

Ivermectin

Kaur, H., Shekhar, N., Sharma, S., Sarma, P., Prakash, A., & Medhi, B. (2021). Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes. Pharmacological reports : PR, 1–14. Advance online publication. https://doi.org/10.1007/s43440-020-00195-y

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