Studies utilizing electronic health record (EHR) data to analyze COVID-19 in patients with chronic liver disease (CLD) have several limitations. Potential issues include under-diagnosis, misdiagnosis, over-diagnosis, and limited information regarding specific treatments or medications. Additionally, EHR analyses may lack detailed socioeconomic and geographic data, and often do not provide a representative sample of the broader population outside the documented US healthcare system.

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A study analyzing electronic health records (EHR) of patients in the United States identified key findings regarding COVID-19 and chronic liver disease (CLD):
- Patients with CLD, particularly those with a recent clinical encounter in the past year, had a significantly higher risk of contracting COVID-19 compared to those without CLD.
- African Americans with CLD were twice as likely to contract COVID-19 compared to Caucasians.
- COVID-19 patients with CLD faced increased hospitalization and mortality rates compared to both COVID-19 negative patients with CLD and COVID-19 positive patients without CLD.

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