• An EKD must be carefully monitored if induced in patients with Type I and Type II diabetes.

• Ketosis only begins 72 hours after the start of the diet.

• Lack of glucose provided by the diet can cause low NADPH/NADP+ ratio.

University of California, Davis

The eucaloric ketogenic diet is a diet consisting of mainly fat and minimal amounts of carbohydrates. It provides the body with sufficient calories while it stabilizes blood glucose levels and reduces oxidative stress.

Eucaloric Ketogenic Diet (EKD)

Sukkar, S. G., & Bassetti, M. (2020). Induction Of Ketosis As A Potential Therapeutic Option To Limit Hyperglycemia And Prevent Cytokine Storm In Covid-19. Nutrition, 110967. doi:10.1016/j.nut.2020.110967

Induction of Ketosis as a Potential Therapeutic Option to Limit Hyperglycemia and Prevent Cytokine Storm in COVID-19

An eucaloric ketogenic diet can help curb cytokine storm syndrome in the following ways:

• Since EKD limits a person's intake on carbohydrates, it can reduce the production of ATP through glycolysis in M1 macrophages during the exudative phase of acute respiratory distress syndrome.

• EKD can prevent cytokines from being overproduced, which in turn limits the accumulation of neutrophils, monocytes and platelets from blood.

• EKD can help with the metabolism of M2 macrophages. M2 macrophages feed on the oxidation of fatty acids in mitochondria, which EKD provides ample of.

• EKD helps keep lactate formation by glycosis in check, making sure that the environment is favorable for the production of type 1 IFNs.

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