The mood stabilizer Lithium has many effects, including changes in second-messengers, probably leading to changes in gene expression and receptor density.

Bowdoin College

Some drugs can impact postsynaptic transmitters by directly altering intracellular signals such as the activation of second messengers, activation of genes, and the production of various proteins.

Drugs modulating intracellular signals postsynaptically

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

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