There were no clinically significant changes related to the administration of low doses of psilocybin and the decrease in depression and anxiety symptoms.

Alma College

The low dose group was administered a 1 to 3 mg dose for every 70kg in the first session to simulate a placebo, and administered with a high dose in the second session which accounts for 22 to 30mg for every 70kg.

Low-dose group in psilocybin double-blind study

Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., Cosimano, M. P., & Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology, 30(12), 1181–1197. https://doi.org/10.1177/0269881116675513 

Psilocybin produces substantial and
sustained decreases in depression and
anxiety in patients with life-threatening
cancer: A randomized double-blind trial

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