It is hypothesized that a targeted Mas receptor, such as AVE0091, could prevent SARS-CoV-2 from entering cells with high ACE2 expression.  If so, this could lessen the morbidity and mortality of COVID-19.  

Using Mas Receptor Activators to Treat or Prevent COVID-19

The receptor for Ang 1-7.  Activation of MasR has the following effects:

- anti-hypertrophic

- anti-fibrotic

- vasodilation

- anti-oxidant

Michigan State University

The seven amino acid long pepetide that is formed when ACE 2 acts on Ang II.  Ang 1-9 and Ang 1-7 are negative regulators of RAS.  Ang 1-7 is biologically active with MasR being its receptor.  This molecule alleviates the effects of Ang II/AT1R and has cardioprotective properties.  

Ang 1-7

Patel, V. B., Zhong, J. C., Grant, M. B., & Oudit, G. Y. (2016). Role of the ACE2/angiotensin 1–7 axis of the renin–angiotensin system in heart failure. Circulation research, 118(8), 1313-1326.

Learn Before

Related

Learn After