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Although both single-subject research and case studies focus in detail on a small number of participants, they differ fundamentally in methodology and data analysis. Case studies represent a qualitative approach focused on understanding people's subjective experience through observation, resulting in relatively unstructured data (such as detailed interviews) that is analyzed using narrative techniques. Conversely, single-subject research is a quantitative approach that seeks to understand objective behavior through strict experimental manipulation and control, yielding highly structured data that is analyzed quantitatively.

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