Clemens, J. Q., Brown, S. O., & Calhoun, E. A. (2008). Mental Health Diagnoses in Patients With Interstitial Cystitis/Painful Bladder Syndrome and Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Case/Control Study. The Journal of Urology, 180(4), 1378–1382. doi:10.1016/j.juro.2008.06.032 


Cleveland State University

Depression and panic disorder are significantly more common in individuals with pelvic pain conditions. Anxiety and depression may be more difficult to treat in patients with urological pain syndromes, even with psychotropic medications.

Interstitial Cystitis and Mental Health

Mental Health Diagnoses in Patients With
Interstitial Cystitis/Painful Bladder Syndrome and Chronic
Prostatitis/Chronic Pelvic Pain Syndrome: A Case/Control Study

Psychological symptoms may be the consequences of trauma caused by bladder pain, urgency, frequency, and nocturia. Individuals may have a reduced quality of life due to the chronic nature of the disorder and increased anxiety surrounding its' low rate of remission. IC symptoms by nature interfere with daily activity, interpersonal relationships, and sexual function, and such consequences could increase emotional distress.

Proposed psychosocial reasons for development of mental disorders in IC patients

It is believed that the that central nervous system is involved in the painful symptoms of IC, as well as anxiety, depression, and insomnia.  The characteristic symptoms of central pain conditions include multifocal pain, fatigue, insomnia, and a higher rate of comorbid mood disorders.

Proposed biological reasons for development of mental disorders in IC patients

A flow chart depicting first through sixth lines of treatment, based on American Urological Association guidelines.

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