• Evaluated clinical outcomes of all consecutive patients hospitalized at HFHS being treated for COVID-19 from March 10, 2020 to May 2, 2020

• Only first admission included for patients with multiple admissions

• COVID-related admission defined as hospitalization with positive RT-PCR test

• All patients were 18 or older and were treated as inpatients for at least 48 hours unless death occurred

• Electronic medical records used for patient demographics and clinical characteristics

Treatments protocol-driven and consistent at all hospitals in health system:

• Hydroxychloroquine dosed at 400 mg twice daily for 2 doses on the first day and 200 mg twice daily on days 2-5

• Azithromycin dosed at 500 mg once daily on first day followed by 250 mg once daily for the next 4 days

• Combination treatment was only used for select patients with severe COVID-19 and minimal cardiac risk factors based on electrocardiogram assessment