Representative Images of Phosphorylated Tau Pathology in mild CTE cases.

Michigan State University

Of 27 diagnosed cases of physically "mild" CTE, 26 (96%) had behavioral and/or mood symptoms, 23 (85%) had cognitive symptoms, and 9 (33%) had signs of dementia. Three of these 27 cases had only ever played football in high school.

Mild CTE in American Football Players

Mez J, Daneshvar DH, Abdolmohammadi B, Chua AS, Alosco ML, Kiernan PT, Evers L, Marshall L, Martin BM, Palmisano JN, Nowinski CJ, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Huber BR, Stein TD, Goldstein LE, Katz DI, Cantu RC, Au R, Kowall NW, Stern RA, McClean MD, Weuve J, Tripodis Y, McKee AC. Duration of American Football Play and Chronic Traumatic Encephalopathy. Ann Neurol. 2020 Jan;87(1):116-131. doi: 10.1002/ana.25611. Epub 2019 Nov 23. PMID: 31589352; PMCID: PMC6973077.

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