A significant difference (p = 0.03) has been observed in the frequency of the V160M mutation in TMPRSS2 in different ethnic groups:

• Indians (MAF = 0.27; variant carriers = 44.60%)

• Europeans (MAF = 0.22; variant carriers = 36.26%)

• Americans (MAF = 0.15; variant carriers = 28.24%)

minor allele frequency (MAF): the frequency of a less common allele in a population

variant carriers: percentage of the population that is a carrier for the mutated gene