- Tissue and Culture Methods
- Vaccines used for Comparison
- Animal Models
- Study Design
- Lung Abnormality Grading System

Methods used in Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

- Figure 8
      - Mean lesions scores were comparable for both sets of mice 
      - Mean eosinophil scores were higher than control groups in both sets of 
         mice.   


University of Michigan - Ann Arbor

- Serum Neutralizing Antibody Titers & Lung Viral Titer Results 
- Lung Histology Results 

Experiment 3: Mouse and SARS-CoV Vaccine Specificity 

Tseng C, Sbrana E, Iwata-Yoshikawa N et al. Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus. PLoS ONE. 2012;7(4):e35421. doi:10.1371/journal.pone.0035421

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

- Figure 7
      - Mean serum neutralization antibody titers were higher in the for DIV 
         group in Balb/c mice than C57BL/S mice 
      - No virus was detected in any group in Balb/c mice, while some groups 
         had detectable levels in C57BL/S mice.


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