Though severe coronavirus disease 2019 (COVID-19) has been reported rarely in children, international data suggest the development of a proinflammatory syndrome with features of Kawasaki disease (KD) or toxic shock syndrome (TSS) in children, possibly related to COVID-19. 

17 patients were selected from Columbia University Irving Medical Center/New York-Presbyterian Morgan Stanley Children’s Hospital in New York City between April 18 and May 5, 2020. 17 previously healthy children and adolescents developed an inflammatory phenotype related to COVID-19. Features overlapped with, but were distinct from, those of KD and TSS. 

Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City

University of Michigan - Ann Arbor

Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 Organized by Country

This study was a case series of 58 hospitalized children throughout England admitted between March 23 and May 16, 2020. The children had persistent fever and met laboratory criteria for PIMS-TS, or "pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2." Clinical and laboratory characteristics were abstracted by medical record review, and were compared with clinical characteristics of patients with Kawasaki disease (KD) (n = 1132), KD shock syndrome (n = 45), and toxic shock syndrome (n = 37) who had been admitted to hospitals in Europe and the US from 2002 to 2019.

In total, 45 of 58 patients (78%) had evidence of current or prior SARS-CoV-2 infection. 

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