Cardiovascular manifestations of MIS-C may require intensive care, resulting in a severe course of disease and significantly reducing mortality. Severe circulatory failure and myocardial inflammation places a substantial burden on the health of MIS-C patients and was present in all recorded deceased. 

Tulane University

- Fever
- Abdominal pain
- Vomiting
- Diarrhea
- Rash
- Bloodshot eyes
- Feeling extra tired
- Neurological symptoms in CNS and PNS

Symptoms of MIS-C According to Centers for Disease Control and Prevention

Hoste, L., Van Paemel, R., & Haerynck, F. (2021). Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. European journal of pediatrics, 180(7), 2019–2034. https://doi.org/10.1007/s00431-021-03993-5

Multisystem inflammatory syndrome in children related to COVID-19: a systematic review

- Encephalopathy
- Meningism
- Headaches
- Ataxia
- Dysarthria
- Dysphagia
- Splenium of the corpus callosum (SCC) lesions

Multisystem Inflammatory Syndrome in Children (MIS-C) in COVID-19 Patients: CNS Symptoms

- Proximal weakness (generalized or bilateral leg weakness)
- Global flaccid weakness
- Urinary retention
- Reduced reflexes

Multisystem Inflammatory Syndrome in Children (MIS-C) in COVID-19 Patients: PNS Symptoms

A significant finding of the Ghent University Hospital’s review, was the notable lack of respiratory symptoms observed in MIS-C patients. In fact, a majority of cases presented with gastrointestinal symptoms rather than the typical respiratory phenotype characteristic of SARS-CoV-2. Considering the pathogenesis of the disease and the respiratory tract tropism characteristic of the virus, MIS-C predominantly affects the GI, cardiovascular and/or neurological organ systems. 

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