- The rectum is the easiest way of administering ozone
- 95-96% of ozone is delivered to the body after being administered through the rectum
- 100% of the ozone administered is delivered to the body when the autohemotherapy route is used
- Less risks when administered through the rectum
- When ozone was administered through the rectum in those with ebola, the success rate came out to be 100%, and patients showed improvement after the first administration


Ozone's Administration

- Ozone can directly deactivate virus action
- Ozone oxides the glycoproteins in the membrane of viruses, preventing them from entering the host cell
- Ozone stimulates the inflammatory pathway to decrease chances of infection
- Ozone modulates the action of Nrf2, which are enzymes that can get rid of ROS
- Ozone maintains a balance between Nrf2 and NF-kB in order to regulate inflammation
- Ozone can stimulate anti-inflammatory cytokines
- Ozone increases oxygen intake in lungs
- Ozone regulates the amounts of prothrombin and fibrinogen


Michigan State University

- Ozone is an unstable molecule that serves as a strong oxidizing agent
- Ozone has anti-inflammatory properties, and serves as an immunomodulator
- When ozone breaks down, it causes blood vessels to become dilated
- Ozone’s impact is dependent on its dosage
- Ozone messengers (ROS and LOPs) provide therapeutic effects
- ROS acts on blood
- LOPs impact the organs in the body
- ROS increases oxygen uptake by red blood cells (preventing hypoxemia) and stimulates white blood cells
- Ozone releases cytokines (which is known to cause inflammation) but can block the NF-kB pathway
- Ozone decrease the number of IL-6 receptors being activated


Ozone's Therapeutic Effect on COVID-19 Patients

Fernández-Cuadros, M. E., Albaladejo-Florín, M. J., Peña-Lora, D., Álava-Rabasa, S., & Pérez-Moro, O. S. (2020). Ozone (O3) and SARS-CoV-2: Physiological Bases and Their Therapeutic Possibilities According to COVID-19 Evolutionary Stage. SN Comprehensive Clinical Medicine, 1-9.

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