Clozapine is absorbed after oral administration, however, it can undergo extensive metabolism. With bioavailability from 12-81%, the administration of clozapine can be seen to have an effect with or without food. The peak time of plasma concentration is approximately 3-4 hours. As it is metabolized in the liver, clozapine may exceed concentrations of parent compounds. There is activity at the D2 and 5-HT2 receptors.