PI4KB is a PI4K that forms phosphatidylinositol 4-phosphate (PI4P).  It is primarily located in the Golgi and trans-Golgi network, and consequently, it is involved in cellular processes including lipid transport, membrane trafficking, cytokinesis, and maintaining lysosomal identity.  PI4KB and its isoform PI4KA are common viral targets because they can be used to create PI4P rich organelles that are important to viral reproduction. 

PI4KB

 Phosphatidylinositol 4-kinases are phosphoinositide kinases that form phosphatidylinositol 4-phosphate (PI4P).  These enzymes can be further classified into type II PI4Ps and type III PI4Ps.  Type II enzymes are localized in the membrane and include the isoforms PI4K2A and PI4K2B.  Type III enzymes include PI4KA and PI4KB.  

Michigan State University

Phosphoinositide kinases are a type of lipid kinases that form phosphoinositides.  Because their products regulate cell life, development, and death, their activity is closely monitored by regulatory proteins, and they can be translocated to produce specific phosphoinositides.  Dysregulation of these enzymes are associated with many human diseases, including cancers, developmental disorders, and immune deficiencies.  Types of phosphoinositide kinases include:

- PI3Ks/type III PI4Ks
- type II PI4Ks
- PIP kinases

Phosphoinositide Kinases

Burke, J. E. (2018). Structural basis for regulation of phosphoinositide kinases and their involvement in human disease. Molecular Cell, 71(5), 653-673.
https://www.sciencedirect.com/science/article/pii/S1097276518306397
doi: 10.1016/j.molcel.2018.08.005

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