- More active in children
- Shrinks as we age
- Contains T cells and plasma cells
- Plasma cells produce immunoglobulin G, an antibody
- IgG3 and 1 provide immunity against some viral infections

Michigan State University

Figure shows the death rate of people of different age ranges due to COVID-19.
- Green --> very low death rate
- Yellow --> low death rate
- Orange --> Slightly high death rate
- Red --> very high death rate

Different age groups and COVID-19 morbiditiy

S. Rehman, T. Majeed, M. A. Ansari et al., Current scenario of COVID-19 in pediatric age group and physiology of immune and
thymus response, Saudi Journal of Biological Sciences, https://doi.org/10.1016/j.sjbs.2020.05.024

Current scenario of COVID-19 in pediatric age group and physiology of immune and thymus response


- When children play outside in the park/schoolyard, they develop antibodies to potential pathogens that could aid in protection against COVID-19
- ACE2
     - Virus binds to ACE2 receptors on the cell membrane
     - Children have higher amounts of ACE in their bodies, which has the opposite effect of 
        ACE2 (less ACE2)
- Chronic illnesses are greater at old age, increasing the number of fatalities in adults with COVID-19 
- Children have healthy lung tissue, as they are less exposed to pollution and smoking


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