- mutation in ORF1ab polyprotein appears as a replacement of proline with leucine at position 323 of RdRp
- P323L mutation associated with increase in mutation rate in the viral genome
- commonly found in severely affected SARS-CoV-2 cases

State University of New York at Stony Brook

Specific Mutations in RNA-Dependent RNA Polymerase

Biswas, S. K., & Mudi, S. R. (2020). Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19. Genomics & Informatics, 18(4).
https://doi.org/10.5808/GI.2020.18.4.e44

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