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Potential mechanisms of action of the fungal bioactive psilocybin in AUD
Psilocybin’s cellular and systemic effects may range from unlocking a transcriptional blockade via epigenetic reprogramming, direct interactions on the receptor level e.g., through stable 5-HT₂A/mGluR2 heterodimerization, interference with altered brain networks to reactivate glutamatergic signaling in the mPFC or may impact on the alcohol or withdrawal induced microglia response.
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