SOURCES OF CARBON AND NITROGEN IN PURINES

• Amino acids: Nitrogen, glutamine, aspartate, glycine, carbons, serine, through N10-formyl THF
• CO2

BIG PICTURE

• We’re going to create an intermediate: IMP
• Then we can make ATP and GTP

Reduced to purine deoxynucleotides dATP, dGTP

STEPS

• Phosphoribosylamine synthesis
• Phosphoribosylamine -> Inosinate and beyond