Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994 Dec 15;121(12):953-9. doi: 10.7326/0003-4819-121-12-199412150-00009. PMID: 7978722. https://doi.org/10.7326/0003-4819-121-12-199412150-00009

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The Fukuda case definition for ME/CFS was the first case definition created and has lesser requirements than subsequent case definitions. To meet this criteria, patients must experience chronic fatigue for at least 6 months along with four or more of the following symptoms: impaired memory or concentration, sore throat, tender lymph nodes, muscle pain, multi-joint pain, headaches, unrefreshing sleep, and post-exertional malaise.

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