1. University of Missouri and John Hopkins Medical School - https://www.uptodate.com/contents/pharmacology-of-mammalian-mechanistic-target-of-rapamycin-mtor-inhibitors/contributors
2. MayoClinic - https://link.springer.com/chapter/10.1007/978-1-4615-1809-9_5
3. U.S. National Library of Medicine - https://pubmed.ncbi.nlm.nih.gov/8594303/



University of California, Santa Cruz

The immunosuppressive properties of rapamycin are primarily produced in two important steps/actions. 

Rapamycyn inhibits the p70 S6 kinase, which is activated upon the catalyzation of the substrate 40S ribosomal subunit S6 protein. By prevent the catalytic activity, rapamycin reduces the translation of certain mRNA, and as a result, decreases protein synthesis 
Rapamcin, consequently, binds to intracellular proteins, creating a complex that ultimately helps increase the efficiency of such immunosuppressants. 


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