1. University of Virginia - https://med.virginia.edu/cell-biology/recent-publication/the-phosphatidylinositol-3-phosphate-5-kinase-inhibitor-apilimod-blocks-filoviral-entry-and-infection/

University of California, Santa Cruz

Apilimod acts as an entry inhibitor, a mechanism proven by its success in blocking Ebola virus infections. As a phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) inhibitor, it prevents alternative splicing triggered by the PIKfyve protein kinase. This action blocks the entry of infectious substances into the cytoplasm, making it a promising candidate for treating filoviral infections.

Learn Before

Related