1. University of Virginia - https://med.virginia.edu/cell-biology/recent-publication/the-phosphatidylinositol-3-phosphate-5-kinase-inhibitor-apilimod-blocks-filoviral-entry-and-infection/

University of California, Santa Cruz

Proven by its success in blocking infections by the Ebola virus, the mode of action for apilimod is an entry inhibitor. Apilimod is a phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) inhibitor and is, thus, able to prevent alternative splicing that would have been triggered by the PIKfyve protein kinase. By doing so, apilimod is able to block entry of foreign or infectious substances into the cytoplasm and, as a result, is considered to be a promising drug in treating filoviral infections.


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