Livne O, Shmulewitz D, Walsh C, Hasin DS. Adolescent and adult time trends in US hallucinogen use, 2002-19: any use, and use of ecstasy, LSD and PCP. Addiction. 2022 Dec;117(12):3099-3109. doi: 10.1111/add.15987. Epub 2022 Aug 17. PMID: 35978453; PMCID: PMC9994631.

Grinnell College

- Psychedelic, hallucinagenic, man-made compound
- Impacts cognitive, emotional, and perceptual processes in the brain through binding to serotonin receptors
- Thought to improve cognition and may have a positive effect on mental health
- Currently illegal in the United States, however, LSD is increasing in its usage

LSD (Lysergic Acid Diethylamide) 

LSD is an agonist of 5-HT with high affinity for 5-HT2A and 5-HT2C and is small enough to pass the BBB being approximately 100 times more potent than psilocybin. Interestingly, LSD is also an agonist of the dopaminergic receptors with relatively high affinity for dopamine 2 receptors and an agonist of the trace amine associate receptor.

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