Refractory disease indicates a resistance to efforts of treating a disease. The term is often used to indicate abnormal cases of patients that are resistant to otherwise typical treatment measures. 

These are the various classification of disease based on the stage of the disease.
-	Acute Disease
-	Chronic Disease
-	Clinical Disease Stage
-	Subclinical Disease Stage
-	Refractory Disease
-	Flare-Up
-	Progressive Disease
-	Terminal Disease Stage
-	Recovery Stage



Categories of Disease Stages

https://en.wikipedia.org/wiki/Disease#:~:text=There%20are%20four%20main%20types,diseases)%2C%20and%20physiological%20diseases.

Disease

An acute disease typically has a rapid and severe onset, but only lasts a short amount of time which is usually a few days to under a month. They can be treated with either short-term care or medication and often result in a full recovery after some time. 

Acute Disease

The term clinical disease is used to define the stage of the disease at which signs and symptoms begin to appear. This is used to separate from the stage of (subclinical) disease that only indicates a state of having been inflicted upon the patient. 

Clinical Disease Stage

The term subclinical disease refers to the period before the presence of signs and symptoms of a disease are recognized (clinical disease stage). This term can be synonymous to silent disease, silent stage, or asymptomatic disease.

Subclinical Disease Stage

Refractory Disease

A flare-up can be used to refer to either a recurrence of the symptoms and signs of the disease, or the onset of more severe symptoms and signs.

Flare-Up

A progressive disease is one where the expected course of the disease is a continual worsening of symptoms and signs that persist until the patient has reached a state of serious debility, organ failure, or death. Progressive diseases are often chronic diseases or degenerative diseases. 

Progressive Disease

The terminal stage of disease is loosely defined as the stage of actively dying. When death is an expected outcome, this term can be used to refer to any time of earlier disease process up to the point of death.

Terminal Disease Stage

The recovery stage occurs when the state of the patient actively engages in recuperation processes to heal. Examples of such can be the physical repairing of damaged organs and tissue and/or the resumption of system functions back to a healthy state.

Recovery Stage

Chronic illnesses (also referred to as chronic disease or condition) is a condition that lasts for a year or more and requires frequent medical care. Chronic conditions can effect or limit the activities in one's daily life.

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