Schizophrenia is linked to elevated dopamine levels in dorsal striatum and reduced cortical dopamine release. It has been suggested that in people with schizophrenia spectrum disorders, traditional cigarette smoking is a way to self-medicate by reducing problems associated with antipsychotic treatment and reducing positive and negative psychotic symptoms. However, some aspects of the above theories are questionable. For example, if smoking traditional cigarettes reduces problems associated with antipsychotic treatment, tobacco consumption in smokers with schizophrenia should be influenced by changes of antipsychotic drugs.