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Replication
- Replication was sought in a meta-analysis of data from 2415 hospitalised Covid-19 cases and 477741 population controls from the Covid-19 Host Genetics Initiative (HGI, mixed ancestry, with UK Biobank cases and controls excluded) and 1128 cases and 679531 controls in the 23andMe Inc “broad respiratory phenotype” (EUR ancestry), which includes cases reported being placed on a ventilator, being administered oxygen, or having pneumonia versus controls who did not report positive tests
- In addition to the locus on chr3 already reported, we found robust replication for the novel associations in four loci from GenOMICC: a locus on chr12 in the OAS gene cluster, near TYK2 on chr19, in DPP9 on chr19, and a locus on chromosome 21, containing the gene IFNAR2
- Three variants, all in a region of chromosome 6 in which population stratification is difficult to control, did not replicate
- To increase power for exploratory analyses, inverse-variance meta-analysis was performed. This revealed one additional (unreplicated) locus in CCHCR1 at genome-wide significance
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Updated 2020-12-13
Tags
SARS-CoV-2 (COVID-19)
Biomedical Sciences