- Self-reported life satisfaction levels after Ayahuasca use.
- Life satisfaction correlation to mindfulness after Ayahuasca use.


Life Satisfaction Levels and Ayahuasca Use

- Non-judging/Non-reacting behaviors and Ayahuasca use
- Duration and amount of mindfulness and Ayahuasca use

Mindfulness Levels and Ayahuasca Use

- Depression scores (BDI and DASS-21 scores) after Ayahuasca use.
- Length of antidepressant effects after Ayahuasca use.
- Effectiveness of Ayahuasca on different depression levels.




Depression Levels and Ayahuasca Use

The study found that:
- Anxiety ratings were significantly reduced one month after use and can continue one year after use.
- A reduction in self-reported stress was shown after all baselines (one day, one month, one year after use).
- The reduction in anxiety may be a correlation between reduced depression and increased mindfulness.
These findings also correlate with other studies results, which may prove that ayahuasca is effective for anxiety treatment as well.


Anxiety and stress levels (measured by DASS-21) related to Ayahuasca Use

Overall there was a significant change in participants depression levels, life satisfaction levels, mindfulness levels, and anxiety/stress levels. Depression and anxiety/stress levels decreased, while mindfulness levels and life satisfaction levels increased.

Syracuse University

Alma College

A study was conducted to test the effectiveness of ayahuasca as a possible treatment for depression. Participants of this study were categorized as having mild to severe depression, a score of 13 or greater on the Beck Depression Inventory (BDI) and symptoms of chronic depression for at least 2 years. Participants were given ayahuasca once and took questionnaires to asses their symptom levels before using ayahuasca, one week after use, one month after, and one year after using ayahuasca.


Therapeutic effects of ayahuasca for clinical depression 

Ayahuasca has been shown to interfere with   DMN function after the administration of the drug. Furthermore, long-term ayahuasca use has led to the increased thickness of the ACC and decreased thickness of the PCC which are key components of DMN.  Studies also show an increase in local network integration as well as a decrease in global network integration.  This also occurs as there is an increase in Shannon entropy across networks. 

DMN modulation by Ayahuasca 

Van oorsouw, K., Toennes, S. W., & Ramaekers, J. G. (2022). Therapeutic effect of an ayahuasca analogue in clinically depressed patients: A longitudinal observational study. Psychopharmacology, 239(6), 1839-1852. https://doi.org/10.1007/s00213-021-06046-9


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