Ohio State University, Columbus

Analysis using flow cytometry determined an increased presence of activated caspase-3, which plays a role in caspase-dependent apoptosis, was observed in Vero E6 cells with expressed ORF3a, indicating that ORF3a of SARS-CoV2 might be able to play a role in inducing apoptosis by increasing caspase-3 levels.

The Role of ORF3a protein in apoptosis of host cells: Caspase-3

Ren, Y., Shu, T., Wu, D. et al. The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Cell Mol Immunol 17, 881–883 (2020). https://doi.org/10.1038/s41423-020-0485-9

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