Virulence factors that are responsible for adhesion and invasion overcome host defenses. *S. pyogenes* invasins allow bacterial cells to adhere to tissues and establish infection. Bacterial proteases unique to *S. pyogenes* aggressively infiltrate and destroy host tissues, inactivate complement, and prevent neutrophil migration to the site of infection.

Virulence Factors of *S. pyogenes* etc.

*S. pyogenes* is one of several species that can cause this rare but potentially-fatal condition; others include *Klebsiella*, *Clostridium*, *Escherichia coli*, *S. aureus*, and *Aeromonas hydrophila*.

University of Southern Mississippi

Streptococcal infections that start in the skin can sometimes spread elsewhere, resulting in a rare but potentially life-threatening condition called necrotizing fasciitis, sometimes referred to as flesh-eating bacterial syndrome.

Necrotizing Fasciitis

https://openstax.org/details/books/microbiology/

Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology.

OpenStax Microbiology Textbook

*S. pyogenes* etc

Infection of fascia and rapidly spreading tissue death, can lead to septic shock and death. 

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