In this vaccine, a strain of Salmonella typhi was produced through the removal of a lipopolysaccharide necessary for pathogenesis. An enzyme necessary for lipopolysaccharide synthesis is defective, therefore the pathogenicity of the bacterium is reduced. 

Tulane University

Similar to live-attenuated viral vaccines, these bacterial vaccines are more effective at eliciting protective immunity because the attenuated bacteria can continue to replicate in order to mimic a real bacterial infection. Although there is still ongoing research to produce new live-attenuated bacterial vaccines, the number remains relatively small. 

Ex:

- Bacille Calmette-Guérin (BCG) Vaccine

- Salmonella typhi Vaccine

Live-attenuated Bacterial Vaccines

Parham, P. (2009). Vaccination to Prevent Infectious Disease. In 1145902806 862124677 J. Foltin (Ed.), The Immune System (3rd ed., pp. 439-440). New York, New York: Garland Science, Taylor &amp; Francis Group.

The Immune System

The most frequently used live-attenuated bacterial vaccine is the BCG vaccine. Derived from the bovine strain of Mycobacterium tuberculosis, this vaccine prevents childhood tuberculosis meningitis. Although BCG is a routine vaccination for children in European countries, it is not used in the United States. 

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