 - Salvage pathway (uses recycled bases)
- Attach these bases to activated ribose platform (PRPP)
- 5-phosphoribosyl-1-pyrophosphate (PRPP)
- - Makes a nucleotide
> More detailed information:
> 5-phosphoribosyl 1-pyrophosphate + guanine
> Yields: Guanosine monophosphate + pyrophosphate
> Enzyme catalyzed, driven forward by PPi -> 2 Pi


Michigan State University

- Salvage Pathway (uses recycled bases)
- De Novo Pathway (making bases)

Nucleotide Synthesis

Salvage Pathway (uses recycled bases)

- Add PRPP + amino acids + ATP + CO2 + more
Makes a nucleotide

- 2 different strategies
> Pyrimidine rings are formed first and then are attached to activated ribose (PRPP)
Make UTP and then CTP
>Ribonucleotides that can be used to make RNA
>Then UTP can make TMP and CTP can make dCTP
>Deoxyribonucleotides that can be used to make DNA
 
> Purine rings are formed piece by piece right on the ribose-based structure (PRPP)
> They first make the intermediate IMP
> Then go to ATP and GTP
> Ribonucleotides that can be made into RNA
> ATP can make dATP and GTP can make dGTP
Deoxyribonucleotides that can be used to make DNA


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