- SARS-CoV-2 infection can induce thrombotic microangiopathy (TMA), which is characterized as blood clot formation in the arteries and capillaries. ADAMTS13 plays a key role in the pathogenesis of TMA.

How ADAMTS13 levels relates to SARS-CoV-2 infection

It has been observed that SARS-CoV-2 can lead to inflammation of the endothelium in the blood vessels, which can then lead to blood clot formation. 

Santa Clara University

- A reduction of ADAMTS13 levels can potentially predict mortality risk for patients infected with SARS-CoV-2

Potential Diagnostic Methods for COVID-19 Mortality Prediction  

- Tiscia, G. L., Favuzzi, G., De Laurenzo, A., Cappucci, F., Fischetti, L., di Mauro, L., Miscio, G., Mirijello, A., Chinni, E., Grandone, E., & CSS COVID-19 Group (2020). Reduction of ADAMTS13 Levels Predicts Mortality in SARS-CoV-2 Patients. TH open : companion journal to thrombosis and haemostasis, 4(3), e203–e206. https://doi.org/10.1055/s-0040-1716379

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