Acharya, A., Kevadiya, B., Gendelman, H., &amp; Byrareddy, S. (2020, June). SARS-CoV-2 Infection Leads to Neurological Dysfunction. Retrieved December 22, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244399/

University of Michigan - Ann Arbor

Case Study to Show Effects

1. In this case study, meningoencephalitis was seen as a major clinical manifestation of COVID-19. In this report, a person with a history of type-2 diabetes presented with a low-grade fever of 100.5 ° F, headache, stiff neck, photophobia, seizure without respiratory distress. Anti-epileptic therapy was started for the management of viral meningitis.                                                                                                                                                        2. The localization of the virus in brain tissues was studied in mice infected with SARS-CoV34 and MERS-CoV13

Results:
1. The clinical progression demonstrated rapid clinical deterioration with disorientation and hallucinations. SARS-CoV-2 detection tests were positive, and she was treated with hydroxychloroquine with improvement in symptoms during a clinical course of 5 days following admission to hospital. In a second case, a young man in his twenties presented total anosmia and ageusia with high suspicion of SARS-CoV-2 infection.                                                                                  
2. As cardio-respiratory impariments cause reflect brainstem dysfunction, it may be repsonsible for ARDS as it is a frequent cause of COVID-19. - Mouse hepatitis virus, porcine hemagglutinating encephalitis virus, feline CoV - Virus can cross epithelal cells

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