Whole body plethysmography (WBP) was used to assess pulmonary function in young mice infected with SARS-CoV-2 MA. Significance was determined using a 2-way ANOVA and Dunnett's multiple comparisons. Error bars represent the standard error. Red lines indicate the transgenic virus, and black lines indicate the WT virus. PenH slightly but significantly increased in mice infected with the MA virus whereas Rpef significantly decreased on 2 days post infection (dpi). This suggests that the mice had impaired lung function at this time point.