1Cademy - Scaffold morphing of arbidol to create analogues for treatment of COVID-19

Concept

Scaffold morphing of arbidol to create analogues for treatment of COVID-19

slight structural modification of arbidol can be used to create various analogues that can hinder interactions between SARS-CoV-2 spike protein, ACE2 and host proteases furin and TMPRSS2
from 569 analogues, 36 were chosen for study for further potential as therapeutics
A_BR4, A_BR9, A_BR18, A_BR22, and A_BR28 may limit interactions between spike protein and ACE2 receptor as well as other proteases
A_BR18 and A_BR28 showed multi-targeting potential
further studies are needed to determine the inhibitory effects on SARS-CoV-2

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Updated 2021-01-18

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