- Seizure threshold is an individual’s balance between inhibition and excitation signals in the brain
- The lower the threshold, the more likely a person is to experience a seizure
- The risk of drug-induced seizure increases when multiple agents with potential risk are administered together 

Rutgers University

- Symptoms associated with drug-induced seizures are similar to those of non-drug related seizures.
- Majority of seizures induced by drugs present as generalized tonic-clonic seizures
- The withdrawal of drugs such as benzodiazepines may provoke seizures
- It is important to consider whether the suspected drug has seizure potential at normal doses or at higher serum concentrations (as is the case with tricyclic antidepressants, theophylline, and clozapine)
- Many substances can lower the seizure threshold and cause seizures




Seizure Disorders

Lane RJ, Routledge PA. Drug-induced neurological disorders. Drugs. 1983;26(2):124-147. doi:10.2165/00003495-198326020-00002



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