Based on the scenario provided, analyze the most likely underlying biological reason for the nurse's reported issues and explain how this reason accounts for their specific symptoms of fatigue, sleep difficulty, and decreased work performance.

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A misalignment between the body's internal biological clock and the external environment, often caused by factors like cross-time-zone travel or rotating work shifts, can lead to various negative effects, including insomnia, excessive sleepiness, and reduced alertness.

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