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Evolutionary Paradox of the Sickle-Cell Gene
Although the genetic mutation that causes sickle-cell anemia often leads to early death, the gene remains relatively common among individuals of African descent. This persistence appears to contradict the notion of "survival of the fittest," which suggests that a disorder causing such severe negative evolutionary effects and low survival rates would naturally become less frequent in a population over time.
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A specific gene variant, which causes a serious blood disorder when two copies are inherited, is found at a significantly higher frequency in populations with ancestry from malaria-prone regions, such as West and Central Africa. Which statement best analyzes the evolutionary reason for the persistence of this otherwise harmful gene variant in these populations?
Example of Survival Advantage for Sickle-Cell Carriers
Ancestry Versus Race in Human Genetics