The mos common symptom of Hansen's Disease are numb and blanched areas of the skin, lesions with nodules. Progressive forms of this disease also have long term tissue and nerve damage.

University of Wisconsin - Madison

*Mycobacterium leprae* causes the infection known as Hansen's Disease. It is often infecting the cooler areas of the human body such as the nose, toes and fingers. 

*Mycobacterium leprae*

https://openstax.org/details/books/microbiology/

Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology.

OpenStax Microbiology Textbook

Signs and Symptoms of Hansen's Disease (Leprosy)

The virulence factors of *Mycobacterium leprae* are the capsule and cell wall that allows this bacterium to invade other cells and destroy neurons. It is also able to resist reactive oxygen species that macrophages produce. 

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