- Spike-Timing-Dependent Plasticity- The timing of action potentials from presynaptic and postsynaptic neurons opened up the research area of synaptic plasticity (Markram et al., 1997)
- Metaplasticity: Keep synapses within a range of activity - makes synapses more adaptable (Markram et al., 2011)

Washtenaw Community College

- Cajal- cerebral gymnastics hypothesis: The brain's capacity increases as the number of connections between its cells increases
- Tanzio - The more one engages in specific learning or practice, the more already existing connections (synapses) between neurons are strengthened. 
- Tanzio's therory ties into hypertrophy, the reinforcement of preexisting connections/synapses 

Background on Synaptic Plasticity 

Markram, H., Lubke, J., Frotscher, M., and Sakmann, B. (1997). Regulation of
synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275,
213–215. doi: 10.1126/science.275.5297.213

Markram et al., 2011

Spike-Timing-Dependent Plasticity (STDP) vs. Metaplasticity

- Structure and function of synapses are intertwined through altering of the structure of neurons while activity-dependent changes happen 

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