- Transentorhinal region to hippocampal formation

Clinical:
- Subjective or objective impairment of memory for recent events 
- Mild spatial disorientation
- Preservation of general cognitive functioning with or without minimum impairment of daily living activities

Michigan State University

- Stages I & II
- Stages III & IV
- Stages V & VI

Alzheimer's Disease Neurofibrillary Degeneration Stages

Šimić, G., Babić Leko, M., Wray, S., Harrington, C. R., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., de Silva, R., Di Giovanni, G., Wischik, C. M., &amp; Hof, P. R. (2017). Monoaminergic neuropathology in Alzheimer’s disease. Progress in Neurobiology, 151, 101–138. https://doi.org/10.1016/j.pneurobio.2016.04.001 

Monoaminergic neuropathology in Alzheimer’s Disease

Stages I & II of Alzheimer's Disease

- Temporal
- Frontal
- Parietal neocortex

Clinical:
- Impaired recall
- Delayed word recall
- Word finding difficulties
- Disorientation in time and space
- Impaired concentration, comprehension, and conceptualization 

Stages III & IV of Alzheimer's Disease

- Unimodal and primary sensory cortex
- Motor cortex

Clinical:
- Disturbances in object recognition
- Perceptual skills
- Motor skills

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