Concept

Statistical analysis for specific to evaluating 28-day mortality in a randomized controlled trial of Dexamethasone (DEX) among hospitalized COVID-19 patients in RECOVERY trial

  • Hazard ratio (HR) from Cox regression used to estimate mortality rate ratio

  • Patients who didn’t make it to the end of follow up (4.8%) were censored or assumed to have survived until end of follow up based on discharge status

  • Kaplan-Meier survival curves used to track cumulative mortality

  • Subgroup analysis: five subgroups based on age, sex, level of respiratory support, days since onset, predicted 29-day mortality risk - Estimated rate ratios and risk ratios (both denoted RR) - Mean age 1.1 years higher in DEC group, so adjusted for age - Results presented with and without adjustment

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Updated 2020-06-26

Tags

SARS-CoV-2 (COVID-19)

Biomedical Sciences