These additional systemic issues are associated with GJH and commonly co-occur: Gastro-Intestinal (GI) issues, sleep disturbances, and fatigue.

Systemic Manifestations Associated with GJH

Systemic manifestations include unusually soft or velvety skin, mild skin hyper-elasticity, atrophic scarring, and/or bruising easily

Ithaca College

Defined by the presence of additional pain, musculoskeletal symptoms,  systemic manifestations, and/or skin abnormalities

The most commons forms of symptomatic GJH are Hypermobility Spectrum Disorder and Hypermobile Ehlers-Danlos Syndrome (Glans et al, 2021).

Symptomatic GJH

Glans, M., Thelin, N., Humble, M. B., Elwin, M., & Bejerot, S. (2021). Association between adult attention-deficit hyperactivity disorder and generalised joint hypermobility: A cross-sectional case control comparison. Journal of Psychiatric Research, 143, 334–340. https://doi.org/10.1016/j.jpsychires.2021.07.006 


Association between adult attention-deficit hyperactivity disorder and generalized joint hypermobility: A cross-sectional case control comparison. 

Diagnosed when an individual has problems caused by hypermobility such as musculoskeletal pain/complications, but none of the conditions specific to Ehlers-Danlos Syndromes

Hypermobility Spectrum Disorder

A group of rare genetic conditions that affect the connective tissues that provide support for blood vessels, tendons, ligaments, bones, internal organs, and skin.

Ehlers-Danlos Syndromes (EDS)

Musculoskeletal complications include limb pain, chronic widespread pain, recurrent dislocations, and/or joint instability.

*only one secondary musculoskeletal manifestation is required to make a diagnosis of Hypermobile Spectrum Disorder for hypermobile individuals* 

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