- circulating Tfh cells (cTfh) are generated during acute SARS-CoV-2 infection
- SARS-CoV-2 cTfh frequencies have been associated with reduced disease severity
- memory cTfh cells are also generated

State University of New York at Stony Brook

Helper T cells are known to be CD4+. Their basic function is to produce cytokines that up regulate the immune system and alert the other phagocytic cells. Helper T cells can be further divided into TH1, TH2 and TH17 cells. TH1 cells stimulate the CD8+cells and macrophages to kill the infected cells.TH2 cells stimulate B cells to produce antibodies. TH17 cells help maintain the mucosal barrier and is involved in auto-immunity. They are also involved in pro-inflammatory response as they recruit neutrophils and macrophages to site of infection. T helper cells recognise MHC class II molecules.

Function of Helper T cells

Sette, A., & Crotty, S. (2021). Adaptive immunity to SARS-CoV-2 and COVID-19. Cell, S0092-8674(21)00007-6. Advance online publication. https://doi.org/10.1016/j.cell.2021.01.007

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