https://www.technologynetworks.com/drug-discovery

Calvin College

- Structure activity relationship (SAR) defined
- Drug ability (preliminary toxicity, hERG)
- Synthetic feasibility 
- Select mechanistic assays
- In vitro assessment of drug resistance and efflux potential
- Evidence of in vivo efficacy of chemical class
- PK/Toxicity of chemical class known based on preliminary toxicity or in silico studies

Characteristics of a Chemical Lead

The connection between the 3D / chemical structure and biological activity in a molecule. Correlations from SAR analysis can be qualitative or quantitative (QSAR).

Structure Activity Relationship

A qualitative procedure used to identify compounds with a desired activity at the drug target. The two main categories of assays in drug discovery are biochemical and cell-based assays.

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