- Most of the viruses belonging to the family of corona and influenza virus are usually incapable of hacking the host genetic sequence, while they might alter the host epigenome
-  It has been demonstrated that several viruses' families antagonize the immune system by employing a series of epigenetic mechanisms, and, likely, the SARS CoV-2 might use the same strategy.

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Epigenetic landscape alteration by viral infection

- Epigenetic landscape alteration by viral infection

Michigan State University

Epigenetics is a key focus of nutritional strategies against COVID-19. Dietary components, such as specific vitamins and supplements, can act as epigenetic modifiers that modulate the immune response to SARS-CoV-2 and may help mitigate epigenetic landscape alterations caused by the viral infection.

Epigenetics in COVID-19 Nutrition

https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-020-00946-x


The epigenetic implication in coronavirus infection and therapy

- Every patient has a different response to COVID-19, which shows that the ability to combat the deadly virus varies individually
> Thus, treatment can be personalized and adjusted to help protect and combat COVID-19 infections, especially in individuals with non-communicable diseases.

FINDINGS
- Micronutrient therapy to be considered and given should be individual centric and based upon time and dose-response manner.
- Vitamin therapy seems feasible at this time due to absence of the vaccine or medication available for care to prevent multiple organ failure and immunologic deaths among COVID-19-positive patients with NCD (non-communicable diseases).
- In order to provide a metabolism for an individual against vitamin deficiency, all individuals should be screened for specific immune cell reactions and the factors represented by the specific NCD. 
- Other factors, such as smoking and drinking, should not be overlooked

Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease?

Summary table of recommended dietary supplements to aid epigenetics responsible for immune response

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